The Keystone Program in Personalized Risk and Prevention
The Potential
“This Keystone Program demonstrates the greatest integration of multiple disciplines across the cancer continuum and has the greatest potential for having an impact on a national and international level.” – Keystone Programs External Review Panel
The Keystone Program in Personalized Risk and Prevention will:
- Allow the identification of at-risk individuals before the development of cancer and provide new opportunities for early intervention.
- Provide strategies for cancer survivors and their families to deal with their known increased risk for cancer or its recurrence.
- Use novel information technology tools that have been developed at Fox Chase to provide health information to health care providers and their patients.
- Facilitate the delivery of cancer prevention guidelines and best practice recommendations to the health care community.
- Put Fox Chase at the national forefront of personalized preventive cancer medicine.
| Pilot Projects Funded 2011 | |
| Project Title | Co-Principal Investigators |
The Virtual Cancer Genetics Clinic: A pilot study of telemedicine delivery of cancer genetic services in community clinics |
Angela Bradbury, M.D. Linda Patrick-Miller, Ph.D. |
Identify risk alleles for breast cancer progression by global allele-specific expression (ASE) |
Xiaowei Chen, Ph.D. Mary Daly, M.D. |
Quantitative, anatomical and functional characterization of the immune response in a mouse model of colitis-associated cancer |
Glenn Rall, Ph.D. Wen Chi Chang, Ph.D. Margie Clapper, Ph.D. Harry Cooper, M.D. |
| Pilot Projects Funded 2010 | |
| Project Title | Co-Principal Investigators |
Analysis of the Progression of Lung Cancer in LSL K-ras Mice |
Hossein Borghaei, D.O. Douglas Flieder, M.D. |
A Study of Knowledge and Perceptions of Breast Cancer Risk and Health Behaviors Among Adolescent Girls at High Risk and Population Risk for Breast Cancer (SOFT: Study of Female teens) |
Angela Bradbury, M.D. Linda Patrick-Miller, Ph.D. |
Anti-inflammatory effects of anthocyanins on dextran sulfate sodium-induced colitis and its associated colorectal dysplasia and cancer |
Wen-Chi Chang, Ph.D. Michael J. Hall, M.D., M.S. |
Molecular imaging consortium for the preclinical Assessment of bioactivatable probes |
Margie Clapper, Ph.D. Harry Cooper, M.D. Minhhuyen Nguyen, M.D. |
Clinical evaluation of MicroRNAs for risk assessment for prostate cancer in high-risk men |
Veda Giri, M.D. Timothy Rebbeck, Ph.D. |
Molecular risk assessment for identifying women with premalignant disease |
Andrew Godwin, Ph.D. Arthur Patchefsky, M.D. |
| Pilot Projects Funded 2008-2009 | |
| Project Title | Co-Principal Investigators |
Analysis of the Progression of Lung Cancer in LSL K-ras Mice |
Hossein Borghaei, D.O. Andres Klein-Szanto, M.D. |
A Study of Knowledge and Perceptions of Breast Cancer Risk and Health Behaviors Among Adolescent Girls at High Risk and Population Risk for Breast Cancer |
Angela Bradbury, M.D. Linda Patrick-Miller, Ph.D. |
Chemopreventive Activity of Anthocyanins Against Colitis-associated Colorectal Dysplasia and Cancer |
Wen-Chi Chang, Ph.D. Michael J. Hall, M.D., M.S. Paul J. Limburg, M.D., M.P.H. |
Development of Strategies for the Early Detection and Prevention of Colorectal Tumors Using Novel Molecular Imaging Tools |
Margie Clapper, Ph.D. Minhhuyen Nguyen, M.D. Harry Cooper, M.D. |
Molecular Risk Assessment in Women with Premalignant Disease |
Andrew Godwin, Ph.D. Mary B. Daly, M.D., Ph.D. Anthony Yeung, Ph.D. Qi Cai, M.D. |
Examination of Plasma Methionine as a Risk Factor for Human Breast Cancer |
Warren Kruger, Ph.D. Mary B. Daly, M.D., Ph.D. |